Our research lies at the interface of cell biology, biophysics, and cancer research. We study how cells break into pieces under certain mechanical constraints. We call this cell fragmentation: the production of biologically active cell fragments driven by actomyosin contractility, membrane remodeling, and scission. This phenomenon appears in several biological contexts and may play important roles in cancer progression, cell communication, and immune interactions. Our goal is to uncover the molecular and physical principles that make cells fragment, and to understand how this process shapes the behavior of both donor cells and the fragments they produce. To do so, we combine quantitative live-cell imaging, membrane mechanics, microfluidic tools, and reconstitution-inspired approaches.