PUBLICATIONS
2022
- A Comberlato, MM Koga, S Nüssing, IA Parish, MMC Bastings Spatially Controlled Activation of Toll-like Receptor 9 with DNA-Based Nanomaterials. Nano letters, Volume 22, Issue 6, March 23, 2022, https://doi.org/10.1021/acs.nanolett.2c00275
- D Morzy, M Bastings Significance of Receptor Mobility in Multivalent Binding on Lipid Membranes. Angewandte Chemie (International ed. in English), Volume 61, Issue 13, March 21, 2022, https://doi.org/10.1002/anie.202114167
2021
- G Sflomos, L Battista, P Aouad, F De Martino, V Scabia, A Stravodimou, A Ayyanan, A Ifticene-Treboux, , P Bucher, M Fiche, G Ambrosini, C Brisken Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1. EMBO molecular medicine, Volume 13, Issue 3, March 05, 2021, https://doi.org/10.15252/emmm.202013180
- S Saghafinia, K Homicsko, A Di Domenico, S Wullschleger, A Perren, I Marinoni, G Ciriello, IP Michael, D Hanahan Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression. Cancer discovery, Volume 11, Issue 10, October 01, 2021, https://doi.org/10.1158/2159-8290.CD-20-1637
- JR Poganik, KT Huang, S Parvez, Y Zhao, S Raja, MJC Long, Y Aye Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera. Nature communications, Volume 12, Issue 1, September 30, 2021, https://doi.org/10.1038/s41467-021-25466-x
- S Van Herck, B Feng, L Tang Delivery of STING agonists for adjuvanting subunit vaccines. Advanced drug delivery reviews, Volume 179, Issue , October 29, 2021, https://doi.org/10.1016/j.addr.2021.114020
- Y Zhao, YQ Xie, S Van Herck, S Nassiri, M Gao, Y Guo, L Tang Switchable immune modulator for tumor-specific activation of anticancer immunity. Science advances, Volume 7, Issue 37, September 10, 2021, https://doi.org/10.1126/sciadv.abg7291
- Y Guo, YQ Xie, M Gao, Y Zhao, F Franco, M Wenes, I Siddiqui, A Bevilacqua, H Wang, H Yang, B Feng, X Xie, CM Sabatel, B Tschumi, A Chaiboonchoe, Y Wang, W Li, W Xiao, W Held, P Romero, PC Ho, L Tang Metabolic reprogramming of terminally exhausted CD8<sup>+</sup> T cells by IL-10 enhances anti-tumor immunity. Nature immunology, Volume 22, Issue 6, June 01, 2021, https://doi.org/10.1038/s41590-021-00940-2
- L Bonati, L Tang Cytokine engineering for targeted cancer immunotherapy. Current opinion in chemical biology, Volume 62, Issue , June 01, 2021, https://doi.org/10.1016/j.cbpa.2021.01.007
- AS Eklund, A Comberlato, IA Parish, R Jungmann, MMC Bastings Quantification of Strand Accessibility in Biostable DNA Origami with Single-Staple Resolution. ACS nano, Volume , Issue , October 06, 2021, https://doi.org/10.1021/acsnano.1c05540
2020
- D Ataca, P Aouad, C Constantin, C Laszlo, M Beleut, M Shamseddin, RD Rajaram, R Jeitziner, TJ Mead, M Caikovski, P Bucher, G Ambrosini, SS Apte, C Brisken The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche. Nature communications, Volume 11, Issue 1, March 26, 2020, https://doi.org/10.1038/s41467-020-15357-y
- E Dheilly, E Battistello, N Katanayeva, S Sungalee, J Michaux, G Duns, S Wehrle, J Sordet-Dessimoz, M Mina, J Racle, P Farinha, G Coukos, D Gfeller, A Mottok, R Kridel, BE Correia, C Steidl, M Bassani-Sternberg, G Ciriello, V Zoete, E Oricchio Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma. Cancer cell, Volume 37, Issue 5, May 11, 2020, https://doi.org/10.1016/j.ccell.2020.03.016
- FPA David, M Litovchenko, B Deplancke, V Gardeux ASAP 2020 update: an open, scalable and interactive web-based portal for (single-cell) omics analyses. Nucleic acids research, Volume 48, Issue W1, July 02, 2020, https://doi.org/10.1093/nar/gkaa412
- R Dainese, V Gardeux, G Llimos, D Alpern, JY Jiang, ACA Meireles-Filho, B Deplancke A parallelized, automated platform enabling individual or sequential ChIP of histone marks and transcription factors. Proceedings of the National Academy of Sciences of the United States of America, Volume 117, Issue 24, June 16, 2020, https://doi.org/10.1073/pnas.1913261117
- G Galliverti, S Wullschleger, M Tichet, D Murugan, N Zangger, W Horton, AJ Korman, LM Coussens, MA Swartz, D Hanahan Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV<sup>+</sup> Cancers. Cancer immunology research, Volume 8, Issue 1, January 01, 2020, https://doi.org/10.1158/2326-6066.CIR-19-0315
- X Liu, MJC Long, BD Hopkins, C Luo, L Wang, Y Aye Precision Targeting of <i>pten</i>-Null Triple-Negative Breast Tumors Guided by Electrophilic Metabolite Sensing. ACS central science, Volume 6, Issue 6, June 24, 2020, https://doi.org/10.1021/acscentsci.9b00893
- MJC Long, Y Zhao, Y Aye Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling Axis. Cell chemical biology, Volume 27, Issue 1, January 16, 2020, https://doi.org/10.1016/j.chembiol.2019.11.012
- K Lei, A Kurum, L Tang Mechanical Immunoengineering of T cells for Therapeutic Applications. Accounts of chemical research, Volume 53, Issue 12, December 15, 2020, https://doi.org/10.1021/acs.accounts.0c00486
- L Wei, Y Zhao, X Hu, L Tang Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine. ACS central science, Volume 6, Issue 3, March 25, 2020, https://doi.org/10.1021/acscentsci.9b01174
- SFJ Wickham, A Auer, J Min, N Ponnuswamy, JB Woehrstein, F Schueder, MT Strauss, J Schnitzbauer, B Nathwani, Z Zhao, SD Perrault, J Hahn, S Lee, MM Bastings, SW Helmig, AL Kodal, P Yin, R Jungmann, WM Shih Complex multicomponent patterns rendered on a 3D DNA-barrel pegboard. Nature communications, Volume 11, Issue 1, November 13, 2020, https://doi.org/10.1038/s41467-020-18910-x
2019
- MC Donaldson-Collier, S Sungalee, M Zufferey, D Tavernari, N Katanayeva, E Battistello, M Mina, KM Douglass, T Rey, F Raynaud, S Manley, G Ciriello, E Oricchio EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains. Nature genetics, Volume 51, Issue 3, March 01, 2019, https://doi.org/10.1038/s41588-018-0338-y
- M Biočanin, J Bues, R Dainese, E Amstad, B Deplancke Simplified Drop-seq workflow with minimized bead loss using a bead capture and processing microfluidic chip. Lab on a chip, Volume 19, Issue 9, April 23, 2019, https://doi.org/10.1039/c9lc00014c
- D Alpern, V Gardeux, J Russeil, B Mangeat, ACA Meireles-Filho, R Breysse, D Hacker, B Deplancke BRB-seq: ultra-affordable high-throughput transcriptomics enabled by bulk RNA barcoding and sequencing. Genome biology, Volume 20, Issue 1, April 19, 2019, https://doi.org/10.1186/s13059-019-1671-x
- N Luong-Gardiol, I Siddiqui, I Pizzitola, B Jeevan-Raj, M Charmoy, Y Huang, A Irmisch, S Curtet, GS Angelov, M Danilo, M Juilland, B Bornhauser, M Thome, O Hantschel, Y Chalandon, G Cazzaniga, JP Bourquin, J Huelsken, W Held γ-Catenin-Dependent Signals Maintain BCR-ABL1<sup>+</sup> B Cell Acute Lymphoblastic Leukemia. Cancer cell, Volume 35, Issue 4, April 15, 2019, https://doi.org/10.1016/j.ccell.2019.03.005
- IP Michael, S Saghafinia, D Hanahan A set of microRNAs coordinately controls tumorigenesis, invasion, and metastasis. Proceedings of the National Academy of Sciences of the United States of America, Volume 116, Issue 48, November 26, 2019, https://doi.org/10.1073/pnas.1913307116
- Q Zeng, IP Michael, P Zhang, S Saghafinia, G Knott, W Jiao, BD McCabe, JA Galván, HPC Robinson, I Zlobec, G Ciriello, D Hanahan Synaptic proximity enables NMDAR signalling to promote brain metastasis. Nature, Volume 573, Issue 7775, September 01, 2019, https://doi.org/10.1038/s41586-019-1576-6
- IP Michael, S Saghafinia, M Tichet, N Zangger, I Marinoni, A Perren, D Hanahan ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis. Developmental cell, Volume 49, Issue 3, May 06, 2019, https://doi.org/10.1016/j.devcel.2019.04.015
- YQ Xie, H Arik, L Wei, Y Zheng, H Suh, DJ Irvine, L Tang Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells. Biomaterials science, Volume 7, Issue 4, March 26, 2019, https://doi.org/10.1039/c8bm01556b
- K Lei, L Tang Surgery-free injectable macroscale biomaterials for local cancer immunotherapy. Biomaterials science, Volume 7, Issue 3, February 26, 2019, https://doi.org/10.1039/c8bm01470a
- A Comberlato, K Paloja, MMC Bastings Nucleic acids presenting polymer nanomaterials as vaccine adjuvants. Journal of materials chemistry. B, Volume 7, Issue 41, November 07, 2019, https://doi.org/10.1039/c9tb01222b
- H Bila, EE Kurisinkal, MMC Bastings Engineering a stable future for DNA-origami as a biomaterial. Biomaterials science, Volume 7, Issue 2, January 29, 2019, https://doi.org/10.1039/c8bm01249k
2018
- P Ginefra, BGH Filippi, P Donovan, S Bessonnard, DB Constam Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7. Cell reports, Volume 22, Issue 8, February 20, 2018, https://doi.org/10.1016/j.celrep.2018.02.005
- E Battistello, N Katanayeva, E Dheilly, D Tavernari, MC Donaldson, L Bonsignore, M Thome, AL Christie, MA Murakami, O Michielin, G Ciriello, V Zoete, E Oricchio Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma. Blood, Volume 131, Issue 21, May 24, 2018, https://doi.org/10.1182/blood-2017-10-809210
- A Coudray, AM Battenhouse, P Bucher, VR Iyer Detection and benchmarking of somatic mutations in cancer genomes using RNA-seq data. PeerJ, Volume 6, Issue , January 01, 2018, https://doi.org/10.7717/peerj.5362
- PC Schwalie, H Dong, M Zachara, J Russeil, D Alpern, N Akchiche, C Caprara, W Sun, KU Schlaudraff, G Soldati, C Wolfrum, B Deplancke A stromal cell population that inhibits adipogenesis in mammalian fat depots. Nature, Volume 559, Issue 7712, July 01, 2018, https://doi.org/10.1038/s41586-018-0226-8
- TM Malta, A Sokolov, AJ Gentles, T Burzykowski, L Poisson, JN Weinstein, B Kamińska, J Huelsken, L Omberg, O Gevaert, A Colaprico, P Czerwińska, S Mazurek, L Mishra, H Heyn, A Krasnitz, AK Godwin, AJ Lazar, , JM Stuart, KA Hoadley, PW Laird, H Noushmehr, M Wiznerowicz Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation. Cell, Volume 173, Issue 2, April 05, 2018, https://doi.org/10.1016/j.cell.2018.03.034
- G Galliverti, M Tichet, S Domingos-Pereira, S Hauert, D Nardelli-Haefliger, MA Swartz, D Hanahan, S Wullschleger Nanoparticle Conjugation of Human Papillomavirus 16 E7-long Peptides Enhances Therapeutic Vaccine Efficacy against Solid Tumors in Mice. Cancer immunology research, Volume 6, Issue 11, November 01, 2018, https://doi.org/10.1158/2326-6066.CIR-18-0166
- L Li, Q Zeng, A Bhutkar, JA Galván, E Karamitopoulou, D Noordermeer, MW Peng, A Piersigilli, A Perren, I Zlobec, H Robinson, ML Iruela-Arispe, D Hanahan GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth. Cancer cell, Volume 33, Issue 4, April 09, 2018, https://doi.org/10.1016/j.ccell.2018.02.011
- Y Fu, MJC Long, S Wisitpitthaya, H Inayat, TM Pierpont, IM Elsaid, JC Bloom, J Ortega, RS Weiss, Y Aye Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3. Nature chemical biology, Volume 14, Issue 10, October 01, 2018, https://doi.org/10.1038/s41589-018-0113-5
- Y Guo, K Lei, L Tang Neoantigen Vaccine Delivery for Personalized Anticancer Immunotherapy. Frontiers in immunology, Volume 9, Issue , January 01, 2018, https://doi.org/10.3389/fimmu.2018.01499
2017
- P Donovan, OA Dubey, S Kallioinen, KW Rogers, K Muehlethaler, P Müller, D Rimoldi, DB Constam Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion. The Journal of investigative dermatology, Volume 137, Issue 12, December 01, 2017, https://doi.org/10.1016/j.jid.2017.07.845
- PC Schwalie, P Ordóñez-Morán, J Huelsken, B Deplancke Cross-Tissue Identification of Somatic Stem and Progenitor Cells Using a Single-Cell RNA-Sequencing Derived Gene Signature. Stem cells (Dayton, Ohio), Volume 35, Issue 12, December 01, 2017, https://doi.org/10.1002/stem.2719
- JP Abbuehl, Z Tatarova, W Held, J Huelsken Long-Term Engraftment of Primary Bone Marrow Stromal Cells Repairs Niche Damage and Improves Hematopoietic Stem Cell Transplantation. Cell stem cell, Volume 21, Issue 2, August 03, 2017, https://doi.org/10.1016/j.stem.2017.07.004
- N Lugli, VS Dionellis, P Ordóñez-Morán, I Kamileri, SK Sotiriou, J Huelsken, TD Halazonetis Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue. Cell reports, Volume 19, Issue 11, June 13, 2017, https://doi.org/10.1016/j.celrep.2017.05.051
- MJ Long, S Parvez, Y Zhao, SL Surya, Y Wang, S Zhang, Y Aye Akt3 is a privileged first responder in isozyme-specific electrophile response. Nature chemical biology, Volume 13, Issue 3, March 01, 2017, https://doi.org/10.1038/nchembio.2284
2016
- B Deplancke, D Alpern, V Gardeux The Genetics of Transcription Factor DNA Binding Variation. Cell, Volume 166, Issue 3, July 28, 2016, https://doi.org/10.1016/j.cell.2016.07.012
- S Khurana, S Schouteden, JK Manesia, A Santamaria-Martínez, J Huelsken, A Lacy-Hulbert, CM Verfaillie Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis. Nature communications, Volume 7, Issue , December 01, 2016, https://doi.org/10.1038/ncomms13500
- Z Tatárová, JP Abbuehl, S Maerkl, J Huelsken Microfluidic co-culture platform to quantify chemotaxis of primary stem cells. Lab on a chip, Volume 16, Issue 10, May 21, 2016, https://doi.org/10.1039/c6lc00236f
- D Bertoldo, MM Khan, P Dessen, W Held, J Huelsken, C Heinis Phage Selection of Peptide Macrocycles against β-Catenin To Interfere with Wnt Signaling. ChemMedChem, Volume 11, Issue 8, April 19, 2016, https://doi.org/10.1002/cmdc.201500557
- F Chiacchiera, A Rossi, S Jammula, A Piunti, A Scelfo, P Ordóñez-Morán, J Huelsken, H Koseki, D Pasini Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity. Cell stem cell, Volume 18, Issue 1, January 07, 2016, https://doi.org/10.1016/j.stem.2015.09.019
- E Allen, P Miéville, CM Warren, S Saghafinia, L Li, MW Peng, D Hanahan Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling. Cell reports, Volume 15, Issue 6, May 10, 2016, https://doi.org/10.1016/j.celrep.2016.04.029
- S Parvez, MJ Long, HY Lin, Y Zhao, JA Haegele, VN Pham, DK Lee, Y Aye T-REX on-demand redox targeting in live cells. Nature protocols, Volume 11, Issue 12, December 01, 2016, https://doi.org/10.1038/nprot.2016.114
2015
- SM Waszak, O Delaneau, AR Gschwind, H Kilpinen, SK Raghav, RM Witwicki, A Orioli, M Wiederkehr, NI Panousis, A Yurovsky, L Romano-Palumbo, A Planchon, D Bielser, I Padioleau, G Udin, S Thurnheer, D Hacker, N Hernandez, A Reymond, B Deplancke, ET Dermitzakis Population Variation and Genetic Control of Modular Chromatin Architecture in Humans. Cell, Volume 162, Issue 5, August 27, 2015, https://doi.org/10.1016/j.cell.2015.08.001
- P Ordóñez-Morán, C Dafflon, M Imajo, E Nishida, J Huelsken HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer. Cancer cell, Volume 28, Issue 6, December 14, 2015, https://doi.org/10.1016/j.ccell.2015.11.001
2013
- N Aghaeepour, G Finak, , , H Hoos, TR Mosmann, R Brinkman, R Gottardo, RH Scheuermann Critical assessment of automated flow cytometry data analysis techniques. Nature methods, Volume 10, Issue 3, March 01, 2013, https://doi.org/10.1038/nmeth.2365
- KJ Petherick, AC Williams, JD Lane, P Ordóñez-Morán, J Huelsken, TJ Collard, HJ Smartt, J Batson, K Malik, C Paraskeva, A Greenhough Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk. The EMBO journal, Volume 32, Issue 13, July 03, 2013, https://doi.org/10.1038/emboj.2013.123
2011
- I Malanchi, A Santamaria-Martínez, E Susanto, H Peng, HA Lehr, JF Delaloye, J Huelsken Interactions between cancer stem cells and their niche govern metastatic colonization. Nature, Volume 481, Issue 7379, December 07, 2011, https://doi.org/10.1038/nature10694
2010
- G Jeannet, C Boudousquié, N Gardiol, J Kang, J Huelsken, W Held Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory. Proceedings of the National Academy of Sciences of the United States of America, Volume 107, Issue 21, May 25, 2010, https://doi.org/10.1073/pnas.0914127107
- M Buchert, D Athineos, HE Abud, ZD Burke, MC Faux, MS Samuel, AG Jarnicki, CE Winbanks, IP Newton, VS Meniel, H Suzuki, SA Stacker, IS Näthke, D Tosh, J Huelsken, AR Clarke, JK Heath, OJ Sansom, M Ernst Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS genetics, Volume 6, Issue 1, January 15, 2010, https://doi.org/10.1371/journal.pgen.1000816
2009
- H Yasrebi, P Sperisen, V Praz, P Bucher Can survival prediction be improved by merging gene expression data sets? PloS one, Volume 4, Issue 10, October 23, 2009, https://doi.org/10.1371/journal.pone.0007431
2008
- I Malanchi, H Peinado, D Kassen, T Hussenet, D Metzger, P Chambon, M Huber, D Hohl, A Cano, W Birchmeier, J Huelsken Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature, Volume 452, Issue 7187, April 03, 2008, https://doi.org/10.1038/nature06835
- G Jeannet, M Scheller, L Scarpellino, S Duboux, N Gardiol, J Back, F Kuttler, I Malanchi, W Birchmeier, A Leutz, J Huelsken, W Held Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin. Blood, Volume 111, Issue 1, January 01, 2008, https://doi.org/10.1182/blood-2007-07-102558
2007
- T Fevr, S Robine, D Louvard, J Huelsken Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Molecular and cellular biology, Volume 27, Issue 21, November 01, 2007, https://doi.org/10.1128/MCB.01034-07
2006
- M Scheller, J Huelsken, F Rosenbauer, MM Taketo, W Birchmeier, DG Tenen, A Leutz Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nature immunology, Volume 7, Issue 10, October 01, 2006, https://doi.org/10.1038/ni1387
2005
- J Dessimoz, C Bonnard, J Huelsken, A Grapin-Botton Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development. Current biology : CB, Volume 15, Issue 18, September 20, 2005, https://doi.org/10.1016/j.cub.2005.08.037
2003
- S Godard, G Getz, M Delorenzi, P Farmer, H Kobayashi, I Desbaillets, M Nozaki, AC Diserens, MF Hamou, PY Dietrich, L Regli, RC Janzer, P Bucher, R Stupp, N de Tribolet, E Domany, ME Hegi Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer research, Volume 63, Issue 20, October 15, 2003, https://doi.org/
- Y Xu, D Banerjee, J Huelsken, W Birchmeier, JM Sen Deletion of beta-catenin impairs T cell development. Nature immunology, Volume 4, Issue 12, December 01, 2003, https://doi.org/10.1038/ni1008
2002
- MH Wong, J Huelsken, W Birchmeier, JI Gordon Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signaling. The Journal of biological chemistry, Volume 277, Issue 18, May 03, 2002, https://doi.org/10.1074/jbc.M200184200
2001
- J Huelsken, R Vogel, B Erdmann, G Cotsarelis, W Birchmeier beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell, Volume 105, Issue 4, May 18, 2001, https://doi.org/10.1016/s0092-8674(01)00336-1
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