Our laboratory sits at the intersection of neuroscience, bioengineering, and oncology. Based at the .NeuroRestore center at CHUV/EPFL, we develop and deploy cutting-edge single-cell genomic and neuroprosthetic technologies to understand and treat diseases of the nervous system. A central focus of our work is using single-nucleus RNA sequencing and spatial transcriptomics to build high-resolution atlases of the injured, degenerating, and malignant nervous system — spanning spinal cord injury, Parkinson's disease, and various brain tumors. These molecular maps are paired with targeted neurosurgical interventions, including epidural electrical stimulation and gene therapies, to develop mechanism-driven treatments that have already been translated into clinical trials. We are now extending this framework into neuro-oncology, investigating how tumors co-opt neuronal architectures and injury-response programs to drive malignant progression.