At the LPCE, we work at the interface of biophysics, chemical, structural, computational and cell biology to uncover the molecular principles that regulate protein and cellular signaling. We use this understanding to (1) design protein systems with novel biosensing and signaling functions for synthetic biology and engineered cell therapeutic applications; (2) predict the effects of genetic variations on protein structure/function for personalized cancer medicine applications.

We are particularly interested in deciphering the molecular underpinnings regulating signaling and transport across biological membranes, which control cellular processes but have been particularly challenging to study experimentally.