The central research focus of the Laboratory of Systems Biology and Genetics (LSBG) is to understand genome organization, regulation, and variation and is broadly partitioned according to three major research pillars :
Techno
In the “Techno” pillar, we are developing novel microfluidic, high-throughput sequencing, single cell omic, and computational approaches, which are used to address biological questions in the other two pillars.
Geno
In the “Geno” pillar, we are examining how variation in the regulatory code affects molecular and organismal diversity, focusing on metabolic traits as well as cancer.
Adipo
In the “Adipo” pillar, we are characterizing the regulatory mechanisms driving mesenchymal stromal cell heterogeneity and function in adipose biology and other metabolically relevant processes.