Research in my laboratory focuses on the immunorecognition of DNA, with a particular emphasis on the cGAS-STING signaling pathway - a pivotal PRR system (Fig. 1). Over the past few years, we have contributed to establish new insights into the functioning and biological relevance of the cGAS-STING signaling pathway. Our current work aims to address pertinent questions in the field of innate DNA sensing with a special emphasis on defining its function in physiological contexts that fall outside its classical, infection-associated realm. We envision that our research efforts on innate DNA sensing will eventually allow us to develop new therapeutic concepts and we are actively pursuing research into the emerging translational domain of innate immune sensing pathways.