PARTICIPATING LABS

Moser, Christophe



Laboratory of Applied Photonics Devices

Our current research focuses on the identification of tumor margins in head and neck cancers using optical methods, to facilitate the removal of the entire tumor during the first resection surgery and avoiding complications linked to a second resection in case of positive surgical margin.

The technology below can be translated to other cancers and we believe the endoscope can be useful for monitoring, and delivering light in deep tissues for photodynamic therapies.


Lab website

Key technologies
  • Fluorescence lifetime imaging (FLIM) of endogenous fluorescence, which we know provides relevant information about the cell's metabolism and allows for a better contrast than solely conventional fluorescence microscopy
  • Machine learning, which allows us to classify normal and tumoral tissues based on their lifetime information
  • Minimally invasive endoscopy, which allows us to probe in deep tissues using a needle-like multimode fiber and reach the >5 mm margin of tissue to observe for the diagnostic
  • Organotypic cell cultures and mouse models to test the probing endoscope and its ability to perform the classification accurately
Key biological questions
  • How much do the relevant lifetime parameters necessary for the classification algorithm vary from patient to patient and location to location?
  • How much do the cultures and mouse model relate to the real human situation?
Contact
Victoria Fay
EPFL STI IEM LAPD
BM 4108 (Bâtiment BM)
Station 17
1015 Lausanne
victoria.fay@epfl.ch

Prof. Christophe Moser
EPFL STI IMT LAPD
BM 4111 (Bâtiment BM)
Station 17
1015 Lausanne
christophe.moser@epfl.ch

Prof. Demetri Psaltis
demetri.psaltis@epfl.ch
 
Focus areas