The laboratory of biomedical microfluidics (LBMM) develops novel approaches for personalized cancer therapy, antibody discovery and T-cell screening.

Personalised medicine: We use microfluidic devices to test drug combinations directly on solid human tumor samples and to predict optimal therapies (e.g. Eduati et al., Nature Communications 2018). Current efforts focus on the development of highly multiplexed transcriptomic readouts (Mathur et al., bioRxivs 2021). In parallel, we are constructing next generation instruments for first clinical trials and prepare the launch of another startup, making our personalized cancer therapy approaches available to the public (TheraMe! Consortium www.besttherapyforme.com).

Therapeutic antibodies and T-cells: Droplet based microfluidics enables to screen a large fraction of the murine and human immune repertoire in a single experiment (e.g. El Debs et al., PNAS 2012, Chaipan et al., Cell Chemical Biology 2017, Shembekar et al., Cell Reports 2018). We are actively exploiting this for novel therapeutic approaches and have founded a biotech startup company translating our results (www.veraxa.de).