PARTICIPATING LABS

Hanahan, Douglas



The Hanahan lab’s research program is focused on elucidating mechanisms of tumor development and progression in genetically engineered mouse models of human cancer, a field Hanahan has helped pioneer, with a particular focus on functional contributions of the disparate cell types of the tumor microenvironment to hallmarks capabilities of cancer, and on applying knowledge of mechanisms to guide combinatorial therapeutic strategies with promise to improve the treatment of human cancers.

Lab website

Key technologies
  • genetically-engineered mouse models (GEMMs) of human cancer
  • mouse models of pancreatic, melanoma, glioblastoma, cervical, breast, and colon cancer
  • single-cell and bulk transcriptome profiling
  • immunohistology
  • cell culture bioassays of functional parameters
Key biological questions
  • mechanisms of invasion and metastasis
  • constitution, regulation, and disruption of the immunosuppressive tumor microenvironment
  • mechanism-guided therapeutic co-targeting
Contact
Agora Translational Cancer Research Center, Bunyon 25A, 5th-floor South, 1011 Lausanne
 
Focus areas